Housing affordability is unfortunatly difficult and salaries much more modest than metro Boston-Providence almost everywhere in the more mountainous and rural areas of New England except maybe in impoverished areas like extreme northern New Hampshire and northern and way down east Maine. Taking that into account, you would most likely find contentment and jobs suiting you and lots of intellectual peers
in the northwestern Vermont arc from Montpelier to Burlington to St. Albans, the Rte US 7 corridor from just south of Williamstown, MA to Middlebury, VT, the Pioneer Valley / Connecticut River Valley area (Amherst-Northhampton-Deerfield to Brattleboro), central southwestern NH (centering on Peterborough) and, of course, the Upper Valley area within 25 miles of Dartmouth University in Hanover, NH.